iTFlow | Cardio Flow Design

iTFlow™

iTFlow™ is a software designed to analyze and visualize blood flow by using 4D Flow MRI images.

Clinical case

This is a case in which new information was obtained via iTFlow™ about a problem in a patient with congenital heart disease that could not be detected by conventional testing. She was a patient with tetralogy of Fallot. As a nurse, she had shortness of breath during the night shift, which forced her to limit her work. Her encounter with Dr. Itatani and iTFlow™ changed her life.

Testimonials

"Cardiac magnetic imaging research has demonstrated the emerging potential of advanced intracardiac flow analysis in heart disease beyond traditional measurements. To that end, iTFlow™ provides a front-line software interface to measure kinetic energies, vortices, and shear stresses inside the heart without the need for complex in-house engineering software. I am excited by the potential of software such as iTFlow™ in bringing intracardiac flow analysis to clinical cardiology." - Dr. Yue-hin Loke, Children's National Hospital

Features of iTFlow™

Heart motion tracking

iTFlow™ has various tools embedded to help you segment several zones and process them very precisely with heart motion tracking.
User friendly interface

Unlike most medical software, iTFlow™ has a comprehensive user interface with a ribbon like Microsoft Office.
This aids you with a quicker workflow.
Configurable display

With iTFlow™, you can display only the information you need to focus on.
Show or hide some layers, the whole 2D or 3D view and even the ribbon menu!
You can also select light or dark theme according to your preference.
Export your work

When your work is done, you can export it to STL, video, image, VTK or DICOM file to connect easily with other software.
You can also export the measurement result to a CSV file.

Visualized Parameters

Energy Loss

iTFlow™ provides precise flow energy loss, a parameter of the cardiac workload.
WSS(Wall Shear Stress)

iTFlow™ provides WSS (wall shear stress), a measurement of mechanical stress on endothelial tissue.
Streamline

Streamlines are lines representing the direction of the blood flow showcasing flow acceleration or deceleration through color contrast.
The structure of vortex flow or flow collision can also be visualized.
Beneficial to visualize flow characteristics at stenosed regions or near the valves
Pathlines

Pathlines enable the visualization of virtual blood particles. This function can be used to visualize flow of particles with start points input by the user.
Helicity

Helicity is the local strength of the helical motion of blood flow.
Vorticity

Vorticity is the local strength of the spinning motion of blood flow.
Here, red represents clockwise flow and blue represents anti-clockwise flow
AFI

AFI (Aneurysm formation indicator) evaluates blood flow stagnation; AFI is an indicator proposed by Mantha et al. to detect zones of flow stagnation where the WSS vector aligns with endothelial cells during the cardiac cycle. The research team simulated the AFI of a para choroidal aneurysm by virtually removing the aneurysm and reconstructing the parent artery and reported that there are areas of relatively low WSS rotation or large negative AFI at the site of the aneurysm. (Mantha A, Karmonik C, Benndorf G, Strother C, Metcalfe R. Hemodynamics in a cerebral artery before and after the formation of aneurysm. Am J Neuroradiol. 2006; 27: 1113-8.)
OSI

OSI represents the temporal variation of WSS.
RRT

RRT (Relative residence time) represents the stagnation time of blood flow.
Motion Tracking

Spatial deformation of DICOM images (Cine, Magnitude, Phase Contrast) are calculated to recreate a 3D mask. Heartbeat motion is tracked over time during this step which enables measurements of time variations such as volumetrics.
PCA

PCA represents the intensity of the flow velocity obtained from MRI.
Valve Tracking

Measurement of flow rate at the valve (and any other region of interest) is possible while incorporating contraction movements of the heart over time to visualize and quantify flow rate during the systolic or diastolic phase.
Vector

Visualization of blood flow vectors in 3D is possible.
Ever-evolving functions

Functions with iTFlow™ are evolving as per the needs of our clients.
Be it Threshold, separation, tracking, angle, distance, flow rate measurement, Velocity Histograms, or Vorticity 3D.
There's much more that iTFlow™ can do for you. Find the one that's right for your needs.

Documents

Product Leaflet

(Updated March 2024)

iTFlow™ Sample Report

(Updated March 2024)

Movies

More Movies

Enabled Devices

We are compatible with most MRI devices that can capture 4D Flow MRI images.
Please feel free to contact us for further details at info@cfd.life.

Minimal Configuration

OS

Windows10 64bit (English or Japanese)
Monitor

Full HD (1920x1080)
Interface

Mouse with a wheel
CPU

Intel® Core™ i5-9400
RAM

16 GB
Video RAM

1 GB
GPU

GPU compatible with OpenGL4 or above

Recommended Configuration

CPU

Intel® Core™ i7-9700K
RAM

32 GB
Video RAM

4 GB

Case Report

More Cases

FAQs

Is it possible to analyze 2D Phase Contrast MRI?

It is possible. Energy loss and flow rate are analyzed in two-dimensional units.
What are the advantages and disadvantages of 2D Phase Contrast MRI?

Since the analysis results are limited to 2-dimensional cross-sections, the desired analysis results cannot be obtained if the characteristic flow, for example, the central axis of the stenotic jet is not captured in the cross-section.
On the other hand, it takes less time for acquisition.
What is the price of the software?

Prices vary depending on the type of license. Please contact us to get a quote for your requirements.

Contact

If you would like to order or have any questions,
please let us know from the following contact form