This study evaluates the relationship between left ventricular mechanical synchrony and intra-left ventricular blood flow energy in patients with ischemic heart disease using a hybrid PET/MR system combined with 4D flow MRI analysis.

In 66 patients undergoing rest and pharmacological stress imaging, the study demonstrated a significant positive correlation between left ventricular ejection fraction and indexed intraventricular kinetic energy, while PET-derived phase analysis parameters showed a weak inverse correlation with flow energy. In contrast, perfusion defect scores were not significantly associated with intraventricular hemodynamics.

These findings suggest that impaired LV mechanical synchrony is associated with reduced intraventricular flow energy, highlighting the potential of integrating PET-derived functional assessment with flow-based hemodynamic analysis in ischemic heart disease.

Ayano Ikeda, Kenji Fukushima, Sachika Ishii, Keiichiro Endo, Masataka Katahira, Naoyuki Ukon, Ryo Yamakuni, Takatoyo Kiko, Takeshi Shimizu, Shiro Ishii, Masayoshi Oikawa, Hiroshi Ito, and Yasuchika Takeishi, "Assessment of left ventricular mechanical synchrony and intraventricular blood flow energy in ischemic heart disease using a hybrid positron emission tomography-magnetic resonance system", International Journal of Cardiology, Volume 449 (2026) https://doi.org/10.1016/j.ijcard.2026.134200.