Early detection of doxorubicin-induced cardiomyopa-thy (DXR-ICM) has become a major objective to reduce heart failure in cancer patients.
They aimed to investigate the usefulness of IVPG to detect cardiac function changes after DXR administration in dogs.
The show that this study revealed that impairment of contractility was the initial changes observed with DXR-ICM in dogs and only IVPG could noninvasively detect subclinical alterations in cardiac function.

Katsuhiro Matsuura, Kenjirou Shiraishi, Ahmed S. Mandour, , Kotomi Sato, Kazumi Shimada, Seijirow Goya, Tomohiko Yoshida, Pitipat Kitpipatkun, Lina Hamabe, Akiko Uemura, Zeki Yilmaz, Mayumi Ifuku, Takeshi Iso, Ken Takahashi and Ryou Tanaka, "The Utility of Intraventricular Pressure Gradient for Early Detection of Chemotherapy-Induced Subclinical Cardiac Dysfunction in Dogs", animals, Published Online (2021) . https://doi.org/10.3390/ani11041122.