The purpose of this study was to evaluate the changes in cardiac function in UC and assess the efficacy of Sal B therapy using IVPG and 2DSTE techniques.
The result that this study confirmed increased ventricular stiffness and fibrosis in UC rats which was potentially treated by Sal B via decreasing edema, inflammation, and fibrosis.

Danfu Ma, Ahmed S. Mandour, Ahmed Elfadadny, Hanan Hendawy, Tomohiko Yoshida, Hussein M. El-Husseiny, Koji Nishifuji, Ken Takahashi, Zhenlei Zhou, corresponding author Yanbing Zhao, and Ryou Tanaka, "Changes in Cardiac Function During the Development of Uremic Cardiomyopathy and the Effect of Salvianolic Acid B Administration in a Rat Model", National Library of Medicine, (2022) 10.3389/fvets.2022.905759.